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Bradykinin receptor B2
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Bradykinin receptor B2 : ウィキペディア英語版
Bradykinin receptor B2

Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.
==Mechanism==
The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.
Kallidin also signals through the B2 receptor. An antagonist for the receptor is Hoe 140 (icatibant).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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